Clinical Implementation

For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder thei..

With significant applications in drug delivery and formulation science, colloids offer the same advantages of typical materials used for release but can be tailored to specific bulk material properties such as release profiles. Colloidal systems have the potential to increase the shelf life and impr..

Presenting the first comprehensive reference on this important new area of research, this book provides an overview of the fundamentals of dermatokinetics: the study of drug uptake into skin layers. It offers a detailed discussion of dermatokinetics that is applicable to any route of administration ..

For most therapeutics, the targets of action are intracellular and/or require penetration across cellular and tissue layers. The design of strategies capable of controlling the transport of therapeutic agents through these physiological barriers has, hence, become an imperative and yet challenging n..

In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This compre..

Addressing concerns for patient welfare while protecting producer reputation, and providing a database for formulation of other products, this multiauthored reference blends fundamental theory and practical advice on drug product stability in scientific, technical, and regulatory environments. It co..

Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject in a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabol..

Filled with strategies for minimizing the adverse effects of injectable drugs, this book provides the scientific background and techniques required to evaluate parenteral formulations with respect to their potential to cause pain, irritation, and muscle damage. The book's editors have selected contr..

This definitive reference explores the various aspects of multiparticulate dosage form development—assessing the in vivo behavior and performance of multiparticulates as well as comparing their market position to other dosage forms. It discusses alternative pelletization techniques such as balling (..

This forward-looking book focuses on the recent advances in nanomedicine and drug delivery. It outlines the extraordinary new tools that have become available in nanomedicine and presents an integrated set of perspectives that describe where we are now and where we should be headed to put nanomedici..

Recent breakthroughs in nanomedicine are now making it possible to deliver drugs and therapeutic proteins to local areas of disease or tumors to maximize clinical benefit while limiting unwanted side effects. This book gives an overview of aspects of nanomedicine to help readers design and develop n..

The concept of the perfect medicine as a molecule that goes with high selectivity to the therapeutic target site, does what it needs to do, and is subsequently cleared from the body is especially relevant now...